Searchable abstracts of presentations at key conferences in endocrinology

ea0029p757 | Endocrine Disruptors | ICEECE2012

Proliferative and apoptotic effects of bisphenol A and its combination with estradiol in human breast carcinoma cells

Havranek T. , Macho L. , Fickova M.

Bisphenol A (BPA) is an endocrine disruptor (ED) used as plasticiser present in plastic products of daily use. The leakage of BPA monomer into food, drinks represents the ubiquitous exposure to the general population. BPA stimulatory effect on breast cancer cells growth in vitro and increased incidence of hormone dependent malignancies suspected BPA from carcinogenic effect.The aim of this study was to investigate the effects of BPA alone and in t...

ea0011p278 | Diabetes, metabolism and cardiovascular | ECE2006

Alcohol intake deteriorates insulin receptors and adipokines expression in rat adipose tissue

Pravdová E , Ficková M , Macho L

The effect of short-term (10 days) and long-term (28 days) intake of alcohol (6% ethanol in tap water) on insulin receptor properties in adipose tissue plasma membranes and adipokines expression in adipose tissue of ad libitum fed male Wistar rats was studied. Control animals (C) had free access to standard laboratory diet. After 10 days of alcohol intake lower body mass gain with no changes in size of both epididymal fat pads and adipocytes was observed. However, long-...